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Acute Pneumonia

MedGen UID:
148154
•Concept ID:
C0740766
•
Disease or Syndrome

Definition

Acute inflammation of the lung parenchyma caused by viruses, bacteria, fungi, radiation treatment, or exposure to chemicals. Signs and symptoms include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, and weakness. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Pneumonia

Professional guidelines

PubMed

Pathophysiology and clinical management of coronavirus disease (COVID-19): a mini-review.
Zhu Y, Sharma L, Chang D
Front Immunol 2023;14:1116131. Epub 2023 Aug 14 doi: 10.3389/fimmu.2023.1116131. PMID: 37646038Free PMC Article
Risk Management and Treatment of Coagulation Disorders Related to COVID-19 Infection.
Zanza C, Racca F, Longhitano Y, Piccioni A, Franceschi F, Artico M, Abenavoli L, Maiese A, Passaro G, Volonnino G, La Russa R
Int J Environ Res Public Health 2021 Jan 31;18(3) doi: 10.3390/ijerph18031268. PMID: 33572570Free PMC Article
Immune Checkpoint Inhibitor Therapy-related Pneumonitis: Patterns and Management.
Kalisz KR, Ramaiya NH, Laukamp KR, Gupta A
Radiographics 2019 Nov-Dec;39(7):1923-1937. Epub 2019 Oct 4 doi: 10.1148/rg.2019190036. PMID: 31584861

Recent clinical studies

Etiology

A cellular census of human peripheral immune cells identifies novel cell states in lung diseases.
Song D, Yan F, Fu H, Li L, Hao J, Zhu Z, Ye L, Zhang Y, Jin M, Dai L, Fang H, Song Z, Wu D, Wang X
Clin Transl Med 2021 Nov;11(11):e579. doi: 10.1002/ctm2.579. PMID: 34841705Free PMC Article
COVID-19 - what should anaethesiologists and intensivists know about it?
Wujtewicz M, Dylczyk-Sommer A, Aszkiełowicz A, Zdanowski S, Piwowarczyk S, Owczuk R
Anaesthesiol Intensive Ther 2020;52(1):34-41. doi: 10.5114/ait.2020.93756. PMID: 32191830Free PMC Article
Influenza virus-related critical illness: pathophysiology and epidemiology.
Kalil AC, Thomas PG
Crit Care 2019 Jul 19;23(1):258. doi: 10.1186/s13054-019-2539-x. PMID: 31324202Free PMC Article
Acute Pneumonia.
Arshad H, Fasanya A, Cheema T, Singh AC
Crit Care Nurs Q 2016 Apr-Jun;39(2):148-60. doi: 10.1097/CNQ.0000000000000108. PMID: 26919676
Acute pneumonia and the cardiovascular system.
Corrales-Medina VF, Musher DM, Shachkina S, Chirinos JA
Lancet 2013 Feb 9;381(9865):496-505. Epub 2013 Jan 16 doi: 10.1016/S0140-6736(12)61266-5. PMID: 23332146

Diagnosis

Influenza virus-related critical illness: pathophysiology and epidemiology.
Kalil AC, Thomas PG
Crit Care 2019 Jul 19;23(1):258. doi: 10.1186/s13054-019-2539-x. PMID: 31324202Free PMC Article
Acute Pneumonia.
Arshad H, Fasanya A, Cheema T, Singh AC
Crit Care Nurs Q 2016 Apr-Jun;39(2):148-60. doi: 10.1097/CNQ.0000000000000108. PMID: 26919676
Acute pneumonia and the cardiovascular system.
Corrales-Medina VF, Musher DM, Shachkina S, Chirinos JA
Lancet 2013 Feb 9;381(9865):496-505. Epub 2013 Jan 16 doi: 10.1016/S0140-6736(12)61266-5. PMID: 23332146
Coccidioidomycosis.
Parish JM, Blair JE
Mayo Clin Proc 2008 Mar;83(3):343-48; quiz 348-9. doi: 10.4065/83.3.343. PMID: 18316002
Legionnaires' disease.
Meyer RD, Finegold SM
Annu Rev Med 1980;31:219-32. doi: 10.1146/annurev.me.31.020180.001251. PMID: 6994607

Therapy

A Gram-negative-selective antibiotic that spares the gut microbiome.
Muñoz KA, Ulrich RJ, Vasan AK, Sinclair M, Wen PC, Holmes JR, Lee HY, Hung CC, Fields CJ, Tajkhorshid E, Lau GW, Hergenrother PJ
Nature 2024 Jun;630(8016):429-436. Epub 2024 May 29 doi: 10.1038/s41586-024-07502-0. PMID: 38811738
Influenza virus-related critical illness: pathophysiology and epidemiology.
Kalil AC, Thomas PG
Crit Care 2019 Jul 19;23(1):258. doi: 10.1186/s13054-019-2539-x. PMID: 31324202Free PMC Article
Acute Pneumonia.
Arshad H, Fasanya A, Cheema T, Singh AC
Crit Care Nurs Q 2016 Apr-Jun;39(2):148-60. doi: 10.1097/CNQ.0000000000000108. PMID: 26919676
Coccidioidomycosis.
Parish JM, Blair JE
Mayo Clin Proc 2008 Mar;83(3):343-48; quiz 348-9. doi: 10.4065/83.3.343. PMID: 18316002
Legionnaires' disease.
Meyer RD, Finegold SM
Annu Rev Med 1980;31:219-32. doi: 10.1146/annurev.me.31.020180.001251. PMID: 6994607

Prognosis

Regulated necrosis in COVID-19: A double-edged sword.
Sun C, Han Y, Zhang R, Liu S, Wang J, Zhang Y, Chen X, Jiang C, Wang J, Fan X, Wang J
Front Immunol 2022;13:917141. Epub 2022 Aug 25 doi: 10.3389/fimmu.2022.917141. PMID: 36090995Free PMC Article
Biomarkers in acute heart failure.
Mallick A, Januzzi JL Jr
Rev Esp Cardiol (Engl Ed) 2015 Jun;68(6):514-25. Epub 2015 Apr 21 doi: 10.1016/j.rec.2015.02.009. PMID: 25911167
Acute pneumonia and the cardiovascular system.
Corrales-Medina VF, Musher DM, Shachkina S, Chirinos JA
Lancet 2013 Feb 9;381(9865):496-505. Epub 2013 Jan 16 doi: 10.1016/S0140-6736(12)61266-5. PMID: 23332146
Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia.
Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA
N Engl J Med 2012 Nov 8;367(19):1814-20. Epub 2012 Oct 17 doi: 10.1056/NEJMoa1211721. PMID: 23075143
Coccidioidomycosis.
Parish JM, Blair JE
Mayo Clin Proc 2008 Mar;83(3):343-48; quiz 348-9. doi: 10.4065/83.3.343. PMID: 18316002

Clinical prediction guides

Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain.
Ma Q, Yao C, Wu Y, Wang H, Fan Q, Yang Q, Xu J, Dai H, Zhang Y, Xu F, Lu T, Dowling JK, Wang C
Sci Adv 2023 Oct 20;9(42):eadi0699. Epub 2023 Oct 18 doi: 10.1126/sciadv.adi0699. PMID: 37851811Free PMC Article
Regulated necrosis in COVID-19: A double-edged sword.
Sun C, Han Y, Zhang R, Liu S, Wang J, Zhang Y, Chen X, Jiang C, Wang J, Fan X, Wang J
Front Immunol 2022;13:917141. Epub 2022 Aug 25 doi: 10.3389/fimmu.2022.917141. PMID: 36090995Free PMC Article
Biomarkers in acute heart failure.
Mallick A, Januzzi JL Jr
Rev Esp Cardiol (Engl Ed) 2015 Jun;68(6):514-25. Epub 2015 Apr 21 doi: 10.1016/j.rec.2015.02.009. PMID: 25911167
Pneumonia-associated acute glomerulonephritis.
Srivastava T, Warady, Alon US
Clin Nephrol 2002 Mar;57(3):175-82. doi: 10.5414/cnp57175. PMID: 11924750
Lactoferrin and the inflammatory response.
Baynes RD, Bezwoda WR
Adv Exp Med Biol 1994;357:133-41. doi: 10.1007/978-1-4615-2548-6_13. PMID: 7762425

Recent systematic reviews

Vitamin D as an adjunct to antibiotics for the treatment of acute childhood pneumonia.
Das RR, Singh M, Naik SS
Cochrane Database Syst Rev 2023 Jan 12;1(1):CD011597. doi: 10.1002/14651858.CD011597.pub3. PMID: 36633175Free PMC Article
Long-lasting consequences of coronavirus disease 19 pneumonia: a systematic review.
Patrucco F, Zeppegno P, Baricich A, Gramaglia CM, Balbo PE, Falaschi Z, Carriero A, Cuneo D, Pirisi M, Bellan M
Minerva Med 2022 Feb;113(1):158-171. Epub 2021 Dec 3 doi: 10.23736/S0026-4806.21.07594-7. PMID: 34856780
Vitamin D as an adjunct to antibiotics for the treatment of acute childhood pneumonia.
Das RR, Singh M, Naik SS
Cochrane Database Syst Rev 2018 Jul 19;7(7):CD011597. doi: 10.1002/14651858.CD011597.pub2. PMID: 30024634Free PMC Article
Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults.
Chang CC, Cheng AC, Chang AB
Cochrane Database Syst Rev 2014 Mar 10;2014(3):CD006088. doi: 10.1002/14651858.CD006088.pub4. PMID: 24615334Free PMC Article
Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults.
Chang CC, Cheng AC, Chang AB
Cochrane Database Syst Rev 2012 Feb 15;(2):CD006088. doi: 10.1002/14651858.CD006088.pub3. PMID: 22336815

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